Haptoglobin was low at the time of admission in children with severe malaria or uncomplicated malaria (severe: 0 [0–4.1] mg/dL; uncomplicated: 1.3 [0–49.3] mg/dL), and increased by the 28-day follow up visit (severe day 28: 13.8 [1.2–44.3] md/dL, p < 0.0001 vs admission; uncomplicated day 28: 18.7 [0.2–59.4] mg/dL, p < 0.07 vs admission). This evidence concerns the gene HP and malaria.