IL-1 is known as one main inducer of IL-2 responsiveness in T-cells, a function severely impaired in HL: lymphocytes prepared from HD lesions have been shown to be defective in producing IL-2 and IL-2 receptors with decreased proliferative response to PHA, with reduced blastogenesis and T-cell colony formation [64–67]. This evidence concerns the gene IL1B and Huntington disease.