Ewaschuk and colleagues suggested that the Bifidobacterium infantis strain increased TEER, ZO-1 and occludin expression in normal T84 cells.[46] In this study we found TNF-α, IL-6 and IFN-γ mRNA expressions were up-regulated in tissue from 5-FU treated mice with mucositis. This evidence concerns the gene TJP1 and mucositis.