Therefore, while the effects of reducing TGFβ2 expression are more complicated than for Ccl5, FAK-dependent TGFβ2 expression does contribute to elevated CD4+FoxP3+CD25+ Tregs in SCC FAK-WT tumors; and in the subset of mice bearing tumors that were able to complete the study, TGFβ2 knockdown also caused tumor regression. This evidence concerns the gene PTK2 and neoplasm.