One report showed that bone marrow cells with miR-155 deficiency increased atherosclerosis in low-density lipoprotein receptor (LDLR)−/− mice fed a high-fat diet by generating a more pro-atherogenic immune cell profile and a more pro-inflammatory monocyte/macrophage phenotype, indicating that miR-155 is atheroprotective in that model[13] whereas another report showed that miR-155 promoted atherosclerosis in apoE-/- mice by repressing B-cell lymphoma 6 protein in macrophages, thus enhancing vascular inflammation, suggesting that miR-155 is proatherogenic [14]. This evidence concerns the gene APOE and atherosclerosis.