AXIN2 and ectodermal dysplasia syndrome: Additionally, in 2009, Marvin et al.[37] described a family with a novel, nonsense AXIN2 mutation (c.1989G>A, p.Tyr663X) segregating in an autosomal dominant pattern with oligodontia and variable other findings, including colonic polyposis, gastric polyps, a mild ectodermal dysplasia phenotype with sparse hair and eyebrows, and early onset colorectal and breast cancers.