Here, we report a comprehensive prognostic analysis that integrates clinicopathological criteria, micro-environmental parameters and selected immunohistochemical markers focusing on the five main molecular groups of breast cancers Luminal A (LA), Luminal B HER2-negative (LBH−), Luminal B HER2-positive (LBH+), Triple negative (TN) and HER2-enriched (H2+) as defined by Goldhirsch et al. (2013) and Maisonneuve et al. (2014). This evidence concerns the gene ERBB2 and breast cancer.