These factors include patient age, histological type and grade, tumor size, lymph node status, estrogen receptor (ER) and progesterone receptor (PR) status, and human epidermal growth factor receptor 2 (HER-2) status (Fitzgibbons et al. 2000; Kalaja 2007; Lester et al. 2009). This evidence concerns the gene ESR1 and neoplasm.