Apo-A1 level was significantly lower in moderate and severe MR: HC (mean: 1.74 ± 0.25), mild MR (mean: 1.77 ± 0.17), moderate MR (mean: 1.63 ± 0.21), severe MR (mean: 1.45 ± 0.22) (p = 0.002). This evidence concerns the gene APOA1 and miotic rate.