CASP8 and Parkinson disease: We have taken advantage of conditional knock-out genetic approaches in the myeloid system, including microglia in the brain, to examine cell-specific effects of caspase-8 signaling in the intranigral LPS model and the acute MPTP model of Parkinson's disease, well-established paradigms of dopaminergic neurodegeneration that induces a robust inflammatory response in the substantia nigra.