EGFR and chronic myelogenous leukemia, BCR-ABL1 positive: Survival is often promoted in tyrosine kinase-driven cancers such as CML and EGFR NSLCL, through repression of Bim transcription and through targeting the Bim protein for proteasomal degradation following Mitogen-activated protein kinase 1 (MAPK1/ERK2)-dependent phosphorylation [304-308].