FOXO3 and non-small cell lung carcinoma: • Paclitaxel induced FoxO3a and Bim expression in MCF-7 cells, both involved in apoptosis.• Knockdown of Bim decreased the susceptibility of non-small-cell lung cancer (NSCLC) cells to paclitaxel-mediated killing.• siRNA silencing of Bim reduced sensitivity of K562 cells to Taxol-induced cell death.