The observation by Nogueira et al. [233] showing that downregulation of SRp55 in β-cells leads to increased expression of BimS and apoptosis, opposes the report of Jiang et al. [235] showing that SRp55 appears necessary for the preferential increase in BimS splicing observed after treating B-RafV600E mutant human melanoma cells with the B-RafV600E inhibitor PLX4720. This evidence concerns the gene BCL2L11 and melanoma.