Bim is crucial for mediating cell death in thymocytes, chronic lymphocytic leukemia, T acute lymphoblastic leukemia and multiple myeloma cells induced by glucocorticoids [14, 21, 49, 63, 158, 517-520], and its expression correlates with therapy response in lymphoid malignancies [518, 521, 522]. This evidence concerns the gene BCL2L11 and B-cell chronic lymphocytic leukemia.