BMCC1 (BNIP2 and Cdc42GAP homology (BCH) motif-containing molecule at the carboxyl-terminal region 1), which is highly expressed in neuronal and epithelial tissues as well as in favorable neuroblastoma, promotes apoptosis by suppressing the PDK1/Akt pathway leading to increased FoxO3a-induced Bim transcription [340]. The gene discussed is FOXO3; the disease is neuroblastoma.