Survival is often promoted in tyrosine kinase-driven cancers such as CML and EGFR NSLCL, through repression of Bim transcription and through targeting the Bim protein for proteasomal degradation following Mitogen-activated protein kinase 1 (MAPK1/ERK2)-dependent phosphorylation [304-308]. Here, MAPK1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.