In contrast, the Bcr-Abl phusion protein in CML activates Akt [332] through Ubiquitin-specific-processing protease 7 (USP7)-mediated nuclear exclusion of PTEN [333] and CK2-mediated phosphorylation and inactivation of PTEN [334]. Here, USP7 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.