Of note, constitutively active Notch1 downregulates Bim expression in other cell types (e.g., T cell acute lymphoblastic leukemia) through induction of c-Myc and repression of PTEN that leads to the activation of the PI3K/Akt/mTOR pathway [294]. The gene discussed is AKT1; the disease is T-cell acute lymphoblastic leukemia.