The Erastin-induced cell death was accelerated in HO-1 overexpressed HT-1080 fibrosarcoma cells in the presence of Erastin 10 μM (19.0%) compared with Erastin 10 μM (57.3%) treatment in control vector overexpressed HT-1080 fibrosarcoma cells (Figure 3B). The gene discussed is HMOX1; the disease is fibrosarcoma.