Hh signalling is one of the fundamental developmental pathways required for correct neural crest patterning (for review see Mishina and Snider, 2014) and disc1 is prominently expressed in neural crest cells (Drerup et al., 2009; Wood et al., 2009), so the craniofacial abnormalities reported in schizophrenia may reflect altered Shh signalling, possibly via DISC1. The gene discussed is SHH; the disease is schizophrenia.