For example, ALCAM18, 19, 20 is associated with breast cancer migration and progression; GRP21, 22 has mitogenic effects on some human breast cancer cell lines; SPARCL123, 24 is relevant to aggressive and invasive tumors and drives disease recurrence of prostate cancers; DHRS225 encodes for Hep27 that is part of the molecular pathway regulating cell cycle and apoptosis in osteosarcoma and MCF7 breast cancer cells; CAMK2N1 plays a tumor suppressive role in prostate cancer and is suggested as a biomarker and therapeutic target of such tumors26. This evidence concerns the gene DHRS2 and osteosarcoma.