Discrepancies between our results and the report by Duda et al., which suggest that AMD3100 was ineffective in HCC tumorigenesis, probably rely on that the CXCR4 antagonist intervention on endogenous CXCR4 high-expression HCC cell line, SK-Hep1, in tumorigenesis in vivo in the present study24. The gene discussed is CXCR4; the disease is hepatocellular carcinoma.