We found that miR-622 mimic suppressed CXCR4 expression in SK-Hep1 cells, whereas anti-miR-622 increased CXCR4 expression in Huh7 cells, which suggested that miR-622 is a specific regulator of CXCR4 in hepatoma cells (Fig. 4d). Here, CXCR4 is linked to hepatocellular carcinoma.