Together, these observations suggest that CTRP6 may play important roles not only in RA but also in other inflammatory diseases that involve AP activation, such as MS, type-1 diabetes52, age-related macular degeneration, systemic lupus erythematosus and glomerulonephritis1, 8, 53. This evidence concerns the gene C1QTNF6 and systemic lupus erythematosus.