In non-tumour cells, HuR is mainly localised in the nucleus, allowing miR-16 to suppress COX-2 expression; however, the redirection of HuR to the cytoplasm in colon cancer cells leads to the stabilisation of COX-2 mRNA through binding to an ARE element, making it less accessible to miR-16 [36]. Here, ELAVL1 is linked to neoplasm.