In colonic epithelial cells, both HGF and KGF are enhanced in IL-1 stimulated production of IL-8 during mucosal inflammations, and IL-8 expression, although promoted as an angiogenic factor in pancreatic tumors, might be playing a significant role in supporting this tumor microenvironment [44,45,46,47,48]. This evidence concerns the gene CXCL8 and neoplasm.