HGF and familial pancreatic carcinoma: Current work from our group also demonstrates a similar effect when silencing of the c-Met receptor in pancreatic cancer cells co-cultured with human-derived pancreatic stromal elements expressing HGF ligand resulted in abrogation of proliferation, invasion, and metastasis These results established a relationship between stromal and cancerous elements with respect to the HGF/c-MET signaling pathway in pancreatic cancer pre-clinical studies.