MEK inhibitors such as CI-1040, PD-0325901, AZD6244, RDEA119/BAY 86-9766, GDC-0973/XL581 and AZD8330/ARRY-424704 which are also being tested clinically target MEK and for a wide variety of cancers, while others such as GSK1120212 target, in addition to MEK, C-Raf, B-Raf V600E and BRAF wild type [145]. Here, BRAF is linked to cancer.