In multivariate models adjusted for age, education, APOE ε4 genotype, total energy intake, alcohol intake, smoking habits, body-mass index (BMI), and supplement use, higher intake of vitamin E at baseline was associated with a lower long-term risk of dementia (p-trend = 0.02). Higher intake of foods rich in vitamin E may modestly reduce long-term risk of dementia and AD. This evidence concerns the gene APOE and Alzheimer disease.