Importantly, two physical interactions between ATG7 and acetyltransferase p300 and between ATG7 and transcription factor p53 have been depicted in human HeLa cervical and HCT116 colon cancer cells, respectively, in the context of limited nutrient availability (Lee and Finkel, 2009; Lee et al., 2012). Here, ATG7 is linked to malignant colon neoplasm.