6-Gingerol, which is the major active component of Z. officinale, induces caspase-3-dependent apoptosis and autophagy in HeLa cells, inhibits the growth of Lovo human colon cancer cells by arresting the cell cycle in the G2/M phase, and effectively suppresses tumor growth in a HCT116 cell xenograft assay via the inhibition of leukotriene A(4) hydrolase (LTA[4]H) [42–44]. Here, CASP3 is linked to malignant colon neoplasm.