Cohorts treated three times with the combination of ATM (5 mg/kg) + NVP-BGT226 (4 mg/kg) and a higher single agent dose of NVP-BGT226 (8 mg/kg) administered twice had no detectable parasites by day 7, but eventually succumbed to infection between days 18 and 23 (Fig. 4A,B). The gene discussed is ATM; the disease is infection.