Due to the tumor-promoting and cell migration-inducing activities of Rac1 and accumulated β-catenin in colon cancer (Fritz et al., 1999; Gómez del Pulgar et al., 2007; Jamieson et al., 2012, ; Jamieson et al., 2014), it is crucial to gain a further understanding of the signaling pathways and underlying mechanisms that contribute to Wnt transactivation. The gene discussed is RAC1; the disease is colonic neoplasm.