To estimate the total genetic load of CRYAB in our cohort of familial cases, we interrogated our cohort of >200 familial cases of congenital cataracts by genotyping closely-spaced STR markers followed by sequencing all coding exons of CRYAB. We identified one additional family, PKCC113 linked to the chromosome 11q23 (Fig 1B) with positive two-point LOD scores (Table 1B). Here, CRYAB is linked to early-onset non-syndromic cataract.