AKT1 and Alzheimer disease: Since PC-PLC inhibition had substantial effects on A431-AD squamous cancer cell proliferation, we investigated the changes induced by D609 (50 μg/ml) on the phosphorylation level of EGFR, as well as on the phosphorylation of ERK1/2 and AKT, in order to elucidate whether the inhibitor could interfere with the activation of the two major signaling pathways responsible for cell growth and survival.