HSPG2 and Alzheimer disease: At a lower D609 dose that did not induce any substantial cytotoxic effect on A431-SPH cells (1.5 μg/ml, IC50 1.6 μg/ml), no alterations were detected in the PC-PLC expression level of A431-SPH cells (Fig 5D), as already observed in HaCaT and A431-AD cells treated with the 50 μg/ml dose of D609 (see Fig 2A).