EPAS1 and neoplasm: However, Biswas et al12 reported that HIF-2α was more tumorigenic in RCC and others even implicated HIF-1α as a tumor suppressor gene.13,14 HIF was considered an unfavorable prognostic marker in other types of tumors such as colorectal cancer15 and gynecological cancer16 using meta-analysis, but its prognosis remained inconclusive in RCC patients.