To this end, treatment with KPT330 has been shown to result in the nuclear enrichment of various proteins e.g., p53, and p21, which then are able to perform their cellular function decreasing the survival rate of the cancer cells as shown in diffuse malignant peritoneal mesothelioma, renal cell carcinoma and leukemias [195,221,222,223]. This evidence concerns the gene TP53 and cancer.