While the effects of genetic polymorphisms for conventional drugs used in the treatment of malaria seems to be well studied, there is no data on the effects of the various antimalarial herbal medicines on CYP2C8 or, vice-versa, there is no data on which herbal medicines are substrates for CYP2C8, information that is important in understanding the differential effects of herbal medicine among populations that are in different geographical locations or of different racial extraction. Here, CYP2C8 is linked to malaria.