MPEG1 and bacterial infectious disease with sepsis: However, CFUs in Perforin-2 −/− mice were significantly higher than in wild-type mice (Figure 7—figure supplement 3) and by day 12, Perforin-2 deficient mice continued to have bacteremia with 100 to 100,000 fold higher MRSA counts in their organs as compared to Perforin-2 heterozygous or wild-type littermates (Figure 7B–E).