As the noradrenergic system in the LC in the brainstem sends projections to virtually all brain structures, including the prefrontal cortex of the cerebrum, and has been proposed to be involved in cognitive function, such as impulsivity, attention, working memory and their associated behaviors in mammals [26–29], we investigated the potential role of the Sirh11/Zcchc16 protein in the noradrenergic system, suggesting the relationship to human mental disorders and the impact on brain evolution in eutherian mammals. This evidence concerns the gene RTL4 and psychiatric disorder.