CCND1 and urinary bladder cancer: Similarly, gain of CFA 13 led to chromosome enrichment of overexpressed genes (4.7 % of overexpressed genes), including the oncogenic transcription factor MYC. Responsible for expediting the cell cycle and bypassing critical checkpoints, MYC has been implicated in numerous human cancers, including bladder cancer [44] and is overexpressed cell lines (fold change = +8.5), along with downstream targets cyclin D1 and D2 (fold change = +2.2 and +14.2, respectively).