So far, polymorphisms in TLR4 and TLR5 have been associated with Inflammatory Bowel disease (IBD) in German Shepherd dogs (GSD) [8], but only protective SNPs from TLR5 have been associated with IBD in other 38 dog breeds [9] There is therefore great interest in the characterization of canine TLRs. Here, TLR4 is linked to inflammatory bowel disease.