Autosomal recessive, primary open-angle glaucoma (POAG) has been very well characterized in the Beagle[142–146] and a Gly661Arg variant in ADAMTS10 has been associated with the condition in Beagles that developed elevated intraocular pressure from 8 to 16 months of age, due to increased resistance to outflow of aqueous humour despite normal appearing open iridocorneal angles[147]. Here, ADAMTS10 is linked to open-angle glaucoma.