EGFR and neoplasm: Many potential factors for an unfavorable outcome such as stage of disease, histology, intracranial extension and recently molecular markers such as EGFR have been studied in the literature.15,17 Our results indicate that besides the known predictive factors, including T-, N-, M- and overall AJCC-stage15, tumour volume is an important predictive factor that should be encountered in the staging system in future.