To evaluate the combined effect of fibulin-3 and SMRP levels in evaluating tumour response to treatment, we constructed multivariate logistic regression models that included two categories of fibulin-3 (> 34.25 ng/ml vs. ≤ 34.25 ng/ml) and two categories of SMRP (>1.50 nmol/L vs. ≤ 1.50 nmol/L). This evidence concerns the gene MSLN and neoplasm.