TLR4 and chronic atrophic gastritis: The polymorphism was associated with hyporesponsiveness to bacterial LPS.37 The association of the TLR-4+896A>G polymorphism identifies subjects who have an increased risk of severe inflammation and subsequently, development of hypochlorhydria and gastric atrophy, which are regarded as the most important precancerous abnormalities.27 However, our results were comparable to those by Garza-Gonzales28 that the TLR-4 polymorphism did not play a role in the development of gastric premalignancies.