IL1B and gastric cancer: IL-1b is 100-times more potent inhibitor of acid secretion than proton pump inhibitors.17 Inhibition of acid secretion may lead to the spread of bacteria from the antrum to the corpus, and consequently the development of corpus predominant gastritis which further leads to the development of gastric cancer.18,19 Three polimorphisms were described in the IL-1B gene at positions −31, −511 and +3954 from the transcription start site.18,20IL-1B-31*C and IL-1B-511*T alleles are associated with decreased acidity in the stomach (hypochlohydria) in response to the infection with H. pylori.