Several polymorphisms are known in the promoter region of TNF-A gene of which −308*G>A was associated with increased production of TNF-α in response to the infection, and increased gastric cancer risk.22–24 El-Omar et al. 25 and Machado et al. 26 found that subject with this polymorphism have almost two-fold increased risk of gastric cancer. The gene discussed is TNF; the disease is gastric cancer.