ENO2 and metastatic malignant neoplasm: Remodelling is stimulated by several molecules that link migratory signals to the actin filaments and are upregulated in invasive and metastatic cancer cells.76 In neuroblastoma cells, gamma-enolase was shown to co-localize with actin filaments, an interaction that depends on the presence of gamma-1-syntrophin.43 Additionally, gamma-enolase C-terminal peptide was shown to regulate RhoA kinase, a regulator of actin cytoskeleton organization.