ENO2 and neoplasm: Increased gamma-enolase levels in extracellular fluids are related to cancer progression and are typical for cancer in advances stages with distant metastases.8,39,80,84–87 The levels of gamma-enolase in non-treated cancer increase proportionally to the tumour mass, stage and number of metastases and are related to worse prognosis, however, the levels are not related to the location of metastases.39