For instance, levels of gamma-enolase in cerebrospinal fluid and serum have been used as a biomarker of cerebral injury and for the assessment of neurological disorders.38,89,90 Gamma-enolase is the only neuroendocrine tumour marker, which is used as a serum marker for follow up and monitoring of therapy effectiveness. Here, ENO2 is linked to neuroendocrine neoplasm.