It may interact with different cytoplasmic, nuclear and membrane molecules and exhibits several other functions besides catalysis.1,20 The nuclear form of alpha-enolase was recognized as Myc promoter-binding protein-1 (MBP-1), an alternative splicing form involved in regulation of transcription by repressing the function of Myc and acting as a tumour suppressor.6,21–23 Alpha-enolase localizes also on cell surface of neuronal, endothelial and hematopoietic cells as well on pancreatic, breast and lung cancer cells. The gene discussed is ENO1; the disease is lung cancer.