ENO2 and neoplasm: Consequently, gamma-enolase induced actin polymerisation and its redistribution to growth cones of neurites.68 Similarly, alpha-enolase was shown to bind to actin and tubulin77 and to mediate invasiveness of tumour cells78 and sensitivity to microtubule targeted drugs.79 These results provide evidence, that gamma-enolase might be involved in migration of tumour cells through interactions with actin filaments and regulation of RhoA kinase function.