Specific interactions with macromolecules may address beta-enolase to the subcellular site where ATP, produced through glycolysis, is most needed for muscular contraction or regeneration.33–35 Increased expression of beta-enolase was detected in rhabdomyosarcoma tissue, which is, to our knowledge, the only evidence that this isoform might be involved in cancer.36,37. Here, ENO3 is linked to rhabdomyosarcoma.