ENO2 and neoplasm: Therefore, their participation to accelerated glycolysis could not be the only contribution to tumour progression.2 Alpha-enolase, the most exhaustively studied enolase isoform, was found to be one of the most frequently altered proteins in human pathologies and suggested as a universal cellular sensor that responds to multiple stimuli and reacts through multiple mechanisms.6,111 Gamma-enolase, sharing high-sequence identity with alpha-enolase, is also emerging as a multi-functional molecule.