Increased serum levels of gamma-enolase were reported also in patients with cancers of nonneuroendocrine origin, such as T-cell leukaemia92, B-cell lymphoma93 and malignant melanoma.94 In general, higher serum levels of gamma-enolase are related to worse prognosis and are the highest in patients with advanced metastatic stage.39 Here, ENO2 is linked to melanoma.