To provide a comprehensive analysis of the mechanisms underlying IGF2 overexpression in adrenal tumors, gene expression levels were integrated with copy number and ploidy analysis, and the DNA methylation status of three DMRs including the ICR upstream of H19 (H19 DMR) and two secondary DMRs (DMR0 and DMR2) within IGF2 (Supplementary Fig. 1, see section on supplementary data given at the end of this article). This evidence concerns the gene IGF2 and adrenal gland neoplasm.