High DNA methylation levels of the imprinting control region were thus mainly observed for samples showing copy number changes of chr11p15.5 as 13/15 ACCs and 6/6 PCCs with copy number changes had increased DNA methylation levels (Fig. 4C and D) and the majority of adrenal tumors (90%) with somatic copy number changes also showed overexpression of IGF2 (Fig. 4D). Here, IGF2 is linked to adrenal gland neoplasm.