In concordance with previous findings, we found a correlation between IGF2 overexpression and the presence of malignant adrenocortical tumors (Ilvesmaki et al. 1993a, Gicquel et al. 1997, Slater et al. 2006, Soon et al. 2009, Ragazzon et al. 2011) as 85% of the ACCs overexpressed IGF2. However, similar to recently published data, the degree of overexpression did not correlate with the Weiss score (Guillaud-Bataille et al. 2014) or other clinical parameters. Here, IGF2 is linked to cancer.