ESR1 and breast carcinoma: For instance, miR-206 expression was higher in ERalpha-negative MB-MDA-231 cells than in ERalpha-positive MCF-7 cells [43], and enforced expression of miR-125a or miR-125b led to coordinate suppression of ERBB2 and ERBB3 in the human breast cancer cell line SKBR3 [44].