Interestingly, the expression of a number of β-catenin target genes associated with cell proliferation, specifically the CCNB1, CCNB2 and MYC genes (61,62), were modulated by LRH-1, suggesting that these genes may be the key mediators of the crosstalk between β-catenin and LRH-1 in CRC. The gene discussed is CCNB2; the disease is colorectal carcinoma.