IL12RB1 and Graves ophthalmopathy: The effect of IL-23 depends on its binding to IL-23R, a heterodimer of the IL-12RB1 subunit22, which was identified as an additional candidate gene in some autoimmune and inflammatory diseases such as inflammatory bowel disease, psoriasis, Graves’ ophthalmopathy, ankylosing spondylitis, and multiple sclerosis23, 24.