The two CYP7B1 SNPs previously suggested to be associated with HIV-1 infection susceptibility (rs6996198 and rs10808739) are located ~177 kb apart and are not in strong linkage disequilibrium (LD) in individuals of European or American descent (r2 = 0.15 and r2 = 0.12, respectively, http://analysistools.nci.nih.gov/LDlink/). The gene discussed is CYP7B1; the disease is HIV-1 infection.