Given these changes, we decided to quantify the effects of LRRK2-in-1 on LRRK2 and phosphorylated (p)LRRK2, under conditions of mitochondrial stress, which may effect mitophagy, autophagy, and fusion/fission in the sporadic PD fibroblasts (Fig. 1b). The gene discussed is LRRK2; the disease is Parkinson disease.