Valinomycin caused a significant increase in the protein levels of pS935 in mutant LRRK2 G2019S (p < 0.05) and sensitive sporadic PD fibroblast lines (p < 0.05), which were significantly reduced by LRRK2-in-1 treatment (p < 0.05), (Fig. 1d). This evidence concerns the gene LRRK2 and Parkinson disease.