LRRK2 and Parkinson disease: We have previously investigated induced pluripotent stem cells (iPSCs) derived from dermal fibroblasts from PD patients harboring mutations in LRRK2 and PINK1 and differentiated to neural cells, following treatment with specific small molecules such as valinomycin, oligomycin, CCCP, and rotenone that are specifically detrimental to mitochondrial function [10].