Levels of LRRK2 phosphorylation at S973 were also decreased to baseline levels following LRRK2 kinase inhibition in mutant LRRK2 G2019S (p < 0.01), mutant LRRK2 R1441C (p < 0.05) and sensitive sporadic PD fibroblast lines (p < 0.05), (Fig. 1f). Here, LRRK2 is linked to Parkinson disease.