Coinciding with the rescue of mitochondrial membrane potential, LRRK2-in-1 also reduced the number of ruptured nuclear membranes in all cell lines and the preferential increase in ruptured nuclei observed in sensitive sporadic PD (p < 0.001) and mutant LRRK2 (G2019S) (p < 0.05) derived fibroblast lines (Fig. 3c). This evidence concerns the gene LRRK2 and Parkinson disease.