At baseline, there was more co-localization of mitochondria and lysosomes in mutant LRRK2 G2019S (p < 0.05) and R1441C (p < 0.05) and highly sensitive sporadic PD (p < 0.05) compared to both healthy subject controls and less-sensitive sporadic PD fibroblast lines (Fig. 5c). Here, LRRK2 is linked to Parkinson disease.