The co-localization of Tom20 and LAMP1 was restored to baseline levels following the co-application of valinomycin and LRRK2-in-1 in mutant LRRK2 G2019S (p < 0.001) and R1441C (p < 0.001) PD and highly sensitive sporadic PD lines (p < 0.001), (Fig. 5a, c). The gene discussed is TOMM20; the disease is Parkinson disease.