The outer mitochondrial fusion protein Mfn2 was selectively increased in less-sensitive sporadic PD lines following valinomycin exposure (p < 0.05), yet was decreased in mutant LRRK2 G2019S (p < 0.05) and R1441C (p < 0.05) PD patient-derived fibroblast lines compared to healthy subject controls (Supp. This evidence concerns the gene LRRK2 and Parkinson disease.