Moreover, in multivariate analysis considering also the effect of treatment, the type of histone H3 mutated was a better predictor for survival length than the DIPG clinico-radiological risk score [28] or the presence of an ACVR1 mutation identified in a subset of DIPG with a less aggressive course [56, 60]. This evidence concerns the gene ACVR1 and diffuse intrinsic pontine glioma.