CRC cell clones expressing L1 in which CLU levels were suppressed displayed a more compact colony morphology (Fig. 4B, L1+shCLU Cl1 and Cl2 compare to L1) and higher levels of E-cadherin (Fig. 4C, lanes 4 and 5 compare to lane 3) as compared to cells overexpressing L1. Here, CDH1 is linked to colorectal carcinoma.