To determine the transcription regulators that are involved in the L1-mediated increase in CLU transcription, we examined the RNA levels of various transcription factors that were reported to regulate CLU transactivation such as AP1 [22], YB1 [23], EGR1 [24], STAT-1 [25] and B-MYB [26] in L1 overexpressing CRC cells. Here, STAT1 is linked to colorectal carcinoma.