p65 overexpressing cells did not display an increase in CLU protein compared to control (Fig. 1B, lanes 4 and 5, compare to lane 1) and CRC cells overexpressing L1 and shRNA to p65 continued to express increased CLU levels compared to control Ls174T cells (Fig. 1B, lanes 6 and 7 compare to lane 1). Here, CLU is linked to colorectal carcinoma.