We thus constructed an array of comparative genomic hybridization profiles for 13 primary (not sub-cloned in vitro) MYCN-amplified neuroblastoma cell lines and found them to be substantially superimposable with those of the tumors reported above (Fig. 1A); our cell-line sample is therefore representative of the genomic alteration pattern of high-risk neuroblastoma tumors. Here, MYCN is linked to neuroblastoma.