Ebihara et al. (2015) have recently reported that seipin-knockout rats show impaired spatial working memory. In addition, we have observed the anxiety- and depression-like phenotypes in systemic seipin-knockout (seipin-sKO) and neuron-specific seipin-knockout (seipin-nKO) mice, but not in fat-specific seipin-knockout mice (Zhou et al., 2014). The gene discussed is BSCL2; the disease is major depressive disorder.