Interestingly, expression analysis of Abhd5tm1aWtsi/+ mice supported this testicular defect and demonstrated the extent to which lacZ was also expressed in the skin (pinna and tail), the major tissue affected in individuals with Chanarin-Dorfman syndrome, and in white and brown adipose tissues (Fig. 7J-L), where Abhd5 could play additional functional roles. This evidence concerns the gene ABHD5 and Dorfman-Chanarin disease.