As for Ftz-F1 orthologs, the human liver receptor homolog-1 (LRH-1) has been associated with colonic, gastric, breast and pancreatic cancer (Annicotte et al., 2005; Schoonjans et al., 2005; Wang et al., 2008; Benod et al., 2011), whereas steroidogenic factor 1 (SF-1) has been implicated in prostate and testicular cancers (Straume et al., 2012; Lewis et al., 2014) and in adrenocortical carcinoma (Doghman et al., 2007). Here, NR5A2 is linked to adrenal cortex carcinoma.