Taken together, these data show that Ets21c and Ftz-F1 are transcriptionally induced in a JNK-Fos-dependent manner and predict that cooperation and/or competition among AP-1, Ets21c and Ftz-F1 contributes to the transcriptome changes and tumor phenotypes in rasV12scrib1 clones. This evidence concerns the gene JUNB and neoplasm.