MAPK8 and neoplasm: Strikingly, inhibition of either Ftz-F1 or Fos (through a kay3 mutant allele, fosRNAi, or overexpression of a JNK-phosphorylation site-deficient FosN-Ala; Ciapponi et al., 2001) improved the pupation rate and suppressed tumor cell spreading into the VNC (Fig. 3A,B; supplementary material Fig. S3A,B; Uhlirova and Bohmann, 2006).