Upon JNK inhibition, the diversity of binding motifs was greatly reduced (Fig. 2A) as the number of deregulated genes decreased relative to rasV12scrib1 clones (Fig. 1A), thus implicating JNK as a master regulator of those TFs that cooperatively drive the altered rasV12scrib1 tumor transcriptome. This evidence concerns the gene MAPK8 and neoplasm.